Constantinos Daskalakis

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GERMANY. iv. IRANIAN STUDIES IN GERMAN: ISLAMIC PERIOD. It is not an easy task to define the subject of this contribution. It cannot be ascribed simply to one particular country, since German is the language used not only in Germany proper, but also in Austria and Switzerland. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

    Professor, EECS, MIT

We identified de novo submicroscopic chromosome 14q The deletion of patient overlaps that of patient and both of these deletions lie entirely within that of patient The minimal common deletion region on chromosome 14q In this paper, we discuss genotype—phenotype correlations for three patients with mild developmental delay and cognitive impairment and minor physical abnormalities, who have similar submicroscopic deletions of chromosome 14q They share similar features of minor dysmorphism, which also resemble those reported for some children with MR and cytogenetically visible deletions of proximal chromosome 14q.

These studies were approved by appropriate ethics boards in Canada and the UK. Their first child is a healthy boy. She had prominent strawberry naevi over her left eyelid, philtrum and occiput at birth. The occipital naevus has persisted, whereas the others have faded. She had hypotonia as an infant that resolved as she grew older. Her eyebrows were rounded with a triangular medial aspect and distal tapering. The posterior portion of the helix and antihelix were fused bilaterally. She had a short nose with small nasal tip and flat nasal bridge, long philtrum and small mouth with prominent Cupid's bow of the upper lip.

She also had micrognathia. Her heels were prominent and her feet were flat with cutaneous syndactyly of the second and third toes. Formal developmental assessment at 4. D Previously published patient A of Zanolli et al. Corpus callosum agenesis, multiple cysts, skin defects and subtle ocular abnormalities with a de novo mutation [45,XX,der 5 , t 5;;14 pter;q Am J Med Genet ; The chromosome with the deletion is probably maternal, based on presence of one informative paternal single nucleotide polymorphism SNP in the interval.

A Child vs father comparison; B child vs mother comparison; C child vs father comparison; D child vs mother comparison. Patient , a boy, was the first child of healthy unrelated parents of Japanese descent. The neonatal course was complicated by respiratory distress, and a ventricular septal defect and large patent ductus arteriosus were diagnosed by echocardiogram.

There were no subsequent cardiac problems. He also showed delays in fine motor and language skills. Ophthalmological and auditory evaluations were both normal. The nose was small with a very flat broad nasal bridge and small nasal tip. He had a bridged palmar crease on the right hand and a single palmar crease on the left hand. He had significant pronation of the left foot, mild syndactyly of the second and third toes and clinodactyly of both fourth toes.

She did not require resuscitation but was admitted to the neonatal unit with respiratory problems and required nasogastric feeding for the first few days of life. Her first year of life was characterised by lack of social interaction. A moderate left alternate convergent squint and hypermetropia were noted. Studies of her parents confirmed that the deletion was de novo. The three patients described present similar degrees of developmental delay and cognitive impairment and a similar mild dysmorphic appearance, despite having different ethnic origins.

Hypotonia in infancy was also reported for all three children. We found published reports on 10 patients with deletions of cytogenetic band 14q No molecular characterisation is available for four other published patients, precluding molecular genotype—phenotype correlations. However, some phenotypic features found in our patients were also noted among these patients, including psychomotor delay, 13 hypotonia, 11 , 13 alternating esotropia, 13 micrognathia 11 and other facial dysmorphisms.

The unavailability of molecular breakpoint mapping for these patients excluded them from molecular genotype—phenotype correlations. The only previously reported patient with a deletion shown molecularly to overlap the region involved in our patients is that described by Zanolli et al. This was a de novo rearrangement involving the paternal chromosomes. The patient described by Zanolli et al. D, 1 Andrew S. D, 1 Michael E. D, 1 Christopher R.

D, 2 John Migaly , M. D, 2 and John E. Author information Copyright and License information Disclaimer. The publisher's final edited version of this article is available at Dis Colon Rectum. See other articles in PMC that cite the published article.

Abstract Background A laparoscopic approach has been proposed to reduce the high morbidity and mortality associated with the Hartmann's procedure for the emergency treatment of diverticulitis.

Objective The objective of our study was to determine whether a laparoscopic Hartmann's procedure reduces early morbidity or mortality for patients undergoing an emergency operation for diverticulitis. Design This is a comparative effectiveness study. Patients All patients who underwent an emergency laparoscopic or open partial colectomy with end colostomy for colonic diverticulitis were reviewed.

Main Outcome Measures The main outcome measures were day mortality and morbidity. Results 1, patients undergoing emergency partial colectomy with end colostomy for diverticulitis were included in the analysis.

Limitations This study is limited by its retrospective nature and the absence of pertinent variables such as postoperative pain indices, time for return of bowel function, and rates of readmission. Conclusions A laparoscopic approach to the Hartmann's procedure for the emergency treatment of complicated diverticulitis does not significantly decrease postoperative morbidity or mortality as compared to the open technique. Introduction The traditional strategy for treating complicated diverticulitis in the emergency setting has been a two-stage approach comprised of an initial sigmoid resection and end colostomy Hartmann's procedure followed by a second surgery to restore intestinal continuity.

Open in a separate window. Summary of statistical methods. Superficial Surgical Site Infection Superficial Surgical Site Infection 11 Discussion In hopes of decreasing the morbidity of the Hartmann's procedure itself and temper its criticism, a laparoscopic approach to the procedure has emerged but has yet to be validated against the standard open approach. Footnotes Conflicts of Interest: Vermeulen J, Lange JF. Treatment of perforated diverticulitis with generalized peritonitis: Prospective multicentre evaluation of adverse outcomes following treatment for complicated diverticular disease.

Primary resection with anastomosis vs. Hartmann's procedure in nonelective surgery for acute colonic diverticulitis: Diseases of the colon and rectum. Resection and primary anastomosis in acute complicated diverticulitis, a systematic review of the literature. Int J Colorectal Dis. Salem L, Flum DR. Primary anastomosis or Hartmann's procedure for patients with diverticular peritonitis? Albrecht R, Bochmann C. Laparoscopic resection for diverticular disease. A case-control study of laparoscopic versus open sigmoid colectomy for diverticulitis.

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Precapitalism and Revolution , Saarbrücken and Fort Lauderdale,

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The intensity of pain was self-documented by the previously instructed patients by choosing a value from a non-linear scale range In conclusion, pomegranate beverage had no significant impact on PSA progression in patients with recurrent and advanced prostate cancer when compared to placebo.

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